Keratocystic odontogenic tumor associated with nevoid basal cell carcinoma syndrome: Similar behavior to sporadic type?
Received 30 December 2008; received in revised form 12 August 2009; accepted 7 October 2009.
Abstract
Objective
The objective of this study was to analyze the expression of proliferative markers and p53 in keratocystic odontogenic tumor (KCOT) sporadic type and KCOT associated with nevoid basal cell carcinoma syndrome (NBCCS).
Study Design and Setting
We performed a cross-sectional study. A total of 19 patients with KCOT were selected from the Oral Pathology Laboratory archives, Central University of Venezuela, from 1995 to 2005.
Subjects and Methods
Twelve cases corresponded to sporadic KCOT, and seven cases were associated with NBCCS. Immunohistochemical analysis for p53, proliferating cell nuclear antigen (PCNA), and Ki-67 was performed in all 19 cases.
Results
Of the seven cases associated with NBCCS, six (86%) were positive for PCNA. From the 12 sporadic cases, nine (75%) were positive for PCNA. Only one case of sporadic KCOT showed Ki-67 positivity. Five of 12 (42%) cases of sporadic KCOT were positive for p53, and only one (14%) case associated with NBCCS was positive for p53.
Conclusion
On the basis of the analysis of the expression of PCNA, Ki-67, and p53, there appears to be no evidence to indicate higher aggressiveness in growth and infiltrative behavior in syndromic KCOT compared with the sporadic type. Therefore, surgical treatment may be approached in the same manner in KCOT sporadic and syndromic with the goal of minimizing recurrence.
aOral Surgery Residency Program, Central University of Venezuela, Caracas, Venezuela
bInstitute of Dental Research, Central University of Venezuela, Caracas, Venezuela
cMolecular Genetics Laboratory of the Oncology and Hematology Institute, Central University of Venezuela, Caracas, Venezuela
dOral Pathology Laboratory, Central University of Venezuela, Caracas, Venezuela
eDepartment of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL
Corresponding author: Patricia DeVilliers, DDS, MS, Department of Anatomic Pathology, University of Alabama at Birmingham, 3556 North Pavilion, 1801 6th Ave South, Birmingham, AL 35249
Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.
ABSTRACT