Sensorineural hearing loss in patients with cystic fibrosis
Received 27 January 2009; received in revised form 9 March 2009; accepted 19 March 2009.
Abstract
Objective
To determine the prevalence of sensorineural hearing loss (SNHL) in cystic fibrosis (CF) patients and its relationship to antibiotic use.
Study Design
Case series with chart review.
Setting
Tertiary care pediatric hospital.
Subjects and Methods
We reviewed the medical records of CF patients seen in our children's hospital between March 1994 and December 2007. Data collected included patient demographics, audiograms, tympanograms, genotype, and use of potentially ototoxic antibiotics.
Results
Seven of 50 (14%) patients had SNHL. Three percent of patients who received ≤10 courses of intravenous aminoglycosides had SNHL versus 43 percent of those who received >10 courses (P < 0.01). No patients who received five or fewer courses of nasal irrigation with aminoglycosides had SNHL versus 23 percent of those who received more than five courses (P < 0.05). Nine percent of patients who received five or fewer courses of macrolides had SNHL versus 60 percent of those who received more than five courses (P = 0.079).
Conclusion
CF patients receiving aminoglycosides are at high risk for developing SNHL.
aDepartment of Otolaryngology and Communication Enhancement, Children's Hospital Boston, Boston, MA
bClinical Research Program, Children's Hospital Boston, Boston, MA
cDepartment of Pulmonary Medicine, Children's Hospital Boston and Harvard Medical School, Boston, MA
dDepartment of Otology and Laryngology, Harvard Medical School, Boston, MA
Corresponding author: Alan G. Cheng, MD, Stanford University, Department of Otolaryngology–Head and Neck Surgery, 801 Welch Rd, Stanford, CA 94305
No sponsorships or competing interests have been disclosed for this article.
ABSTRACT