The value of narrow band imaging endoscope for early head and neck cancers
Presented at the Annual Meeting of the American Academy of Otolaryngology–Head and Neck Foundation, Washington, DC, September 16-19, 2007.
Received 4 August 2007; received in revised form 5 December 2007; accepted 26 December 2007.
Objectives
To evaluate the diagnostic value of rhinolaryngoscopy using a narrow band imaging (NBI) system in detecting squamous cell carcinoma of the head and neck (SCCHN) in patients with esophageal cancer (EC).
Study Design
Prospective study.
Subjects and Methods
Between January 2006 and December 2006, 667 consecutive EC patients underwent rhinolaryngoscopy screening with both a white light and an NBI system. Sensitivity, specificity, accuracy, and positive/negative predictive values for detecting SCCHNs were calculated and compared.
Results
Forty-five patients (6.7%) of 667 patients had SCCHNs. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for detecting SCCHNs by white light were 51.1 percent, 99.7 percent, 96.4 percent, 92 percent, and 96.6 percent. In contrast, those by NBI were 97.7 percent**, 98.9 percent, 98.8 percent*, 86.3 percent, and 99.8 percent** (*P < 0.01, **P < 0.001 vs white light).
Conclusion
An NBI endoscope significantly improves diagnostic accuracy, sensitivity, and negative predictive value in detecting SCCHN in EC patients. This endoscope would be highly beneficial in detecting superficial SCCHNs in high-risk patients.
aDepartment of Otolaryngology, Keiyukai Sapporo Hospital, Sapporo, Japan
bDepartment of Surgery, Keiyukai Sapporo Hospital, Sapporo, Japan
cKeiyukai Institute of Clinical & Surgical Pathology, Sapporo, Japan
dDepartment of Medical Science, Health Science University of Hokkaido, Ishikari-tobetsu, Japan.
Corresponding author: Akihito Watanabe, MD, Department of Otolaryngology, Keiyukai Sapporo Hospital, Kita 1-1, Hondori 14-chome, Shiroishi-ku, Sapporo 003-0027 Japan.
ABSTRACT