The effects of intradermal and topical mitomycin C on wound healing
Presented at the Annual Meeting of the American Academy of Otolaryngology–Head and Neck Surgery, September 2004.
Objective
To determine the effect of intradermal and topical mitomycin C (MMC) on skin wound healing.
Study design/setting
A prospective, controlled study in a rat wound model performed in an academic medical center.
Results
Intradermal and topical MMC application decreased wound integrity when compared with saline-treated animals at 1 week, 2 weeks, 1 month, and 6 months. Skin necrosis occurred in animals that received intradermal MMC. Hemotoxylin and eosin and immunohistochemical staining showed no consistent difference between treatment arms. Fibrosis and collagen deposition were reduced in MMC-treated wounds on trichrome staining.
Conclusions
MMC-treated wounds showed decreased wound strength compared with controls. Intradermal MMC can cause skin necrosis. Histologic findings did not always correspond with clinical data.
Significance
The data suggest cautious use of MMC in clinical situations when wound breaking strength is critical.
aMike O’Callaghan Federal Hospital, Nellis Air Force Base, Nevada
bNellis AFB; the Anderson Cancer Center, Houston, TX
cUniversity of Missouri-Columbia, Columbia, Missouri
Reprint requests: Glen T. Porter, MD, Department of Otolaryngology–Head and Neck Surgery, Mike O’Callaghan Federal Hospital, Nellis Air Force Base, NV 89191-6601.
Principal funding for this project was provided by a UTMB-Galveston Department of Otolaryngology–Head and Neck Surgery research grant.
ABSTRACT